Lethal Mutations and Balanced Lethal Systems in Aspergillus nidulans
نویسندگان
چکیده
منابع مشابه
Diagnosis of nonsense mutations in Aspergillus nidulans.
Three genotypically suppressible alleles, a1X4, alcA125, and niaD500, are phenotypically suppressed by aminoglycoside antibiotics. Unsuppressible alleles at these loci are unaffected as are known missense mutations at the yA and gdhA loci. This is consistent with the premise that the suppressible mutations are nonsense and that this highly-allele-specific phenotypic suppression can be used to d...
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The effects of various lethal mutations were studied when they were present in the hemizygous state as sectors in genetic mosaics (gynandromorphs) of Drosophila melanogaster. Sixty percent of the lethals studied can survive to adulthood in combination with normal tissue in mosaics, whereas the remainder cause the death of such mosaic animals. Some of the gynandromorph-viable lethals appeared to...
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Six recessive lethal mutants of Anopheles albimanus are described. Homozygotes for three of the autosomal mutants, viz., bar eye, dot eye and hairy, die during the last larval or early pupal stages; complete linkage data are lacking for bar eye and hairy but dot eye is tightly linked to red eye on the right arm of chromosome 2. Larval and pupal mortality is high for homozygotes of the other two...
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A total of 7,416 ethyl methanesulfonate (EMS)-treated second chromosomes and 6,212 EMS-treated third chromosomes were screened for sex-specific lethals. Four new recessive male-specific lethal mutations were recovered. When in homozygous condition, each of these mutations kills males during the late larval or early pupal stages, but has no detectable effect in females. One mutant, mlets, is a t...
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N T H E mouse a peculiar relation exists amongst three lethal mutations I which produce similar effects on development. Animals which inherit two doses of the same lethal die as early embryos, while those which inherit one dose each of two different lethals of this group may be viable. This is the result to be expected when the lethals involved occupy different loci, but in the present case the...
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ژورنال
عنوان ژورنال: Journal of General Microbiology
سال: 1967
ISSN: 0022-1287
DOI: 10.1099/00221287-49-1-149